US BIOLOGIC Delivers Disease Prevention®.

US Biologic One Health


Different Species – Different Routes – Different Vaccines

Each animal species is different, as are its feeding habits, its environments, and its microbiome. Understanding an animal's digestive tract is essential in delivering vaccines to the right place in the animal's intestines.

Field Mouse

  • Diverse genetic background
  • Can carry multiple pathogens
  • Outdoors
  • Large numbers
  • Multiple environments
  • Uncontrolled eating habits
  • Single-stomach digestive tract


  • Mixed-breed or pure-breed
  • Indoor or outdoors
  • Multiple sizes / breeds
  • Large numbers
  • Controlled or uncontrolled eating habits
  • Strong preferences for certain foods
  • Single-stomach digestive tract


  • Controlled breeding
  • Food animal
  • Multiple stocks and lifespans (breeder, broiler, layer)
  • Large numbers
  • Special feed / water requirements (focus on nutrition)
  • Single stomach with crop digestive tract


  • Controlled breeding
  • Multiple breeds / sizes
  • Food animal (meat and milk)
  • Long lifespan
  • Special feed / water requirements (focus on nutrition)
  • Multi-stomached digestive tract
Human outline



Substrate Component Features

  • Integration of species-specific substrates that allows integration of multiple vaccines, therapeutics, and additives, each of which may be incorporated as an amalgam or as a spray-on.
  • Targeted gut placement that maintains in harsh GI environments.
  • Coarse textures, providing mechanical stimulation of the animal’s innate immune system.
  • Kibble, chewables; effervescent tablets, and powders.

Bacterial Expression Vehicle Component

  • Vehicle inactivation (non-GMO, thermostability).
  • Recombinant antigen expression system (AVOIDS use of infectious agents).
  • Molecular adjuvantization (cost reduction / no chemical complications).
  • Microbiome friendly
General-Example-Bacterial-Vehicle-and-Protein copy

Chemical Encapsulation Component

  • Targeted gut placement.
  • High-throughput, low-cost, and resistant to heat.
  • Thermostability



Manufacturing Features

  • No lyophilization.
  • Low-cost capital equipment build / compact design.
  • Non-centralized manufacturing.
  • Modular equipment design.
  • High throughput with maintained batch consistency.


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Wickramasuriya SW, Park I, Lee Y, et al. Oral Delivery of Bacillus subtilis Expressing Chicken NK-2 Peptide Protects Against Eimeria acervulina Infection in Broiler Chickens. Front. Vet. Sci., 04 June 2021. doi: 0.3389/fvets.2021.684818.

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Gomes-Solecki M. Blocking pathogen transmission at the source: reservoir targeted OspA-based vaccines against Borrelia burgdorferiFront Cell Infect Microbiol. 2014;4:136. doi: 10.3389/fcimb.2014.00136.

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Meirelles Richer L, Aroso M, et al. Reservoir targeted vaccine for Lyme borreliosis induces a yearlong, neutralizing antibody response to OspA in white-footed miceClin Vaccine Immunol. 2011 Nov;18(11):1809-16. doi: 10.1128/CVI.05226-11.

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Composition & Method for Reducing Zoonotic Infectious Disease

Composition & Method of an Orally Administered Antimicrobial Peptide Vectored in a Bacterial Expression Vehicle

Method to Reduce Tick Population with a Universal Tick Antigen

Oral E. coli Vector-Based Vaccine for Prevention of Coccidiosis in Poultry

Oral Vaccine for Borrelia

Time Release Application and Monitoring System

Viral-Vectored Composition and Method of Use